Local Immune Response in Skin of Generalized Vitiligo Patients
نویسندگان
چکیده
منابع مشابه
Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo.
BACKGROUND In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance of melanocytes has, however, not been clearly observed and consequently the aetiology of the disease (autoimmune, neural, cytotoxic) is still elusive. The starting point of vitiligo macules is frequently determined by local conditions such as wounds and excoriations, but may also follow ...
متن کاملNew insights in vitiligo: cellular immune response
Background Vitiligo is a skin disorder that affects 1% to 2% of the world population, independently of ethnicity. It presents with white plaques and skin discoloration. The presence of antibodies against melanocytes confirms the autoimmune phenomena in this disease. Regarding cellular imune response in active vitiligo, it seems to be an imbalance between T cell CD8+ and CD4+, and, moreover, an ...
متن کاملVitiligo and auto immune diseases: A survey of 100 patients
Vitiligo is an autoimmune skin disease which is characterized by depigmented patches due to loss of pigment cells. Evidence suggests that cell-mediated immunity plays a role in melanocyte destruction while some patients have antibodies to melanocytes or melanocytic proteins. Vitiligo is strongly associated with a number of autoimmune disorders. Autoimmune thyroiditis is the most prevalent disea...
متن کاملEvaluation of the therapeutic effect of coenzyme Q10 in patients with generalized vitiligo
Background: Vitiligo is a skin autoimmune disease that affects 0.1% to more than 8% of people in the world. About 50% of patients develop the disease before the age of 20. In this disease, melanocytes are destroyed in the skin, mucous membranes and retina. As a result, white spots appear on different parts of the body. Studies have suggested the role of oxidative stress in vitiligo. Coenzyme Q1...
متن کاملEvaluation of relationship between skin involvement and hearing loss in patients with vitiligo
Vitiligo is a common acquired depigmented disorder of the skin that can lead to social negative outcomes, including reduced quality of life. Melanocytes disorder can also occur within other organs, such as ear. Different areas of the inner ear, such as the cochlear duct and vestibular system, have melanocytes. This study was conducted with the aim of evaluating the relationship between skin inv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2000
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3780138